The College of Pharmacy at the University of Basrah discussed a Master's thesis titled "Computational Design, Synthesis, and Biological Activity Study of Curcumin Derivatives," presented by the student Emad Khalaf Hassan.
The thesis aimed to study the effective pharmacological activity of curcumin, which has limited applications due to its rapid degradation in alkaline and neutral environments caused by the beta-diketone group and acidic hydrogen at the alpha carbon.
The study focused on utilizing green chemistry to synthesize curcumin and its derivatives under ultrasound radiation, and the synthesis of dihydro-4-pyridone derivatives using microwave conditions. Research included evaluating the biological activity of the synthesized compounds as antioxidants and anti-cancer agents against breast (MDA-MB-231) and lung (A549) cancer cell lines.
The thesis concluded with a computational study using molecular docking analysis to evaluate the binding interactions of the studied compounds, enhancing the understanding of the molecular mechanisms of these innovative derivatives.
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