The study by researcher (Ahmed Nizar Manahi) revealed the potential of using Immunoinformatics to produce COVID-19 vaccines derived from the protein sequences of specific bacteria and probiotics.
The thesis involved advanced techniques including gold nanotechnology and indirect ELISA tests to detect cross-reactivity between bacterial antigens and COVID-19 antibodies. The immune response of Pfizer-vaccinated and unvaccinated individuals was examined against bacterial species such as (E. coli, Pseudomonas, Staphylococcus), utilizing Bioinformatics servers from the National Center for Biotechnology Information (NCBI) and the BLASTp tool for protein alignment analysis.
Results and Future Prospects:
The results proved high-level cross-reactivity in ELISA tests, with a significant correlation between the serum of vaccinated individuals and isolated bacterial antigens. These data suggest the possibility of strengthening the immune system using bacterial probiotics and open horizons for manufacturing innovative vaccines based on epitope cross-reactivity, enhancing the effectiveness of the immune response against coronaviruses.
This study consolidates the role of the College of Pharmacy at the University of Basrah as a leading center in immunological and biotechnological research, contributing rigorous scientific solutions to global health crises by integrating computer science with medical and pharmaceutical sciences.
UNIVERSITY OF BASRAH | PHARMACEUTICAL BIOTECHNOLOGY | MASTER'S DEFENSE
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