A Master's thesis at the College of Pharmacy, University of Basrah, examined "The Nephroprotective Effects of Soy Isoflavones Compared to Carvedilol in Rat Models with Glycerol-Induced Acute Kidney Injury". The thesis, presented by the student Hawraa Mohammed Hassan, aimed to evaluate the potential protective effects of carvedilol, genistein, and daidzein on glycerol-induced acute kidney injury and its impact on heart function.
The study involved using a glycerol solution to induce acute renal failure through rhabdomyolysis and the generation of oxidative stress. Carvedilol, genistein, and daidzein were able to restore kidney function and mitigate histological changes. According to the biochemical and histological results of this work, carvedilol, genistein, and daidzein offer protection for both the kidneys and the heart against glycerol-induced injury.
The findings demonstrated that the glycerol solution induced acute renal failure by reducing the weight of the rats and significantly increasing traditional serum biomarkers for kidney injury, such as creatine kinase, albumin, urea, and creatinine, as well as beta-2 microglobulin in the urine. The glycerol solution also exhibited a significant adverse effect on troponin, which was further supported by the presence of substantial histological changes in the kidneys and heart. Additionally, supplements containing carvedilol, genistein, and daidzein provide protection against kidney and heart injuries resulting from the glycerol solution.
