A master's thesis was discussed at the College of Pharmacy at the University of Basrah entitled "The Gastroprotective Effect of Fruit and Seed Extracts, and a Combination of Both, from Iraqi Date Palm on Ethanol-Induced Gastric Ulcer in Rats."
The thesis, presented by student Mustafa Kadhim Hussein, aimed to study the gastroprotective benefits of the Iraqi Barhi date palm (Phoenix dactylifera L. Cv. "Barhi") against ethanol-induced gastric ulcer models in rats.
The results showed that the total phenols in the date fruit and seeds reached 7.25 gallic acid equivalents / 100 g and 1.88 gallic acid equivalents / 100 g, respectively, while the total flavonoids present in the date fruit and seeds were 3.5 quercetin equivalents / 100 g and 1.4 quercetin equivalents / 100 g, respectively. Ethanol produced a gastric ulcer by increasing the gastric volume content and the concentration of hydrochloric acid in rats. In addition, the content of gastrin and hydrochloric acid in the blood increased significantly after ethanol treatment.
On the other hand, ethanol significantly reduced antioxidant activity when measured by glutathione concentrations in serum and gastric tissues. Furthermore, the intestinal mucosa of the animals was significantly negatively affected by ethanol, as evidenced by swelling, erosion, redness of the mucosal tissue surface, and perforation, which led to linear scaly bleeding.
A decrease in the content of gastric volume and hydrochloric acid was also observed in rats administered with the fruit extract alone or a combination of seed and fruit extracts, with a significant decrease in gastrin concentration, and an increase in glutathione concentrations in serum and gastric tissues in the treatments of rats with Iraqi Barhi date extract.
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