The College of Pharmacy at the University of Basrah successfully held the defense of a Master's thesis entitled: "Application of Quality by Design and Quantitative Digital Analysis for the Development of a Swellable Gastroretentive Drug Delivery System for Metoprolol Tartrate", submitted by researcher Mustafa Musa Khalaf Namoq.
The study employed a full factorial design using Design-Expert software to investigate the effect of independent variables (HPMC and Carbopol). Based on the factorial design outcomes, 16 different formulations were prepared by solvent casting method using varying amounts and ratios of polymers.
The dependent variables were the swelling index and in-vitro drug release behavior. Formulation F14 was selected as the optimized formula due to its high swelling index and favorable drug release profile, releasing 86.24% of Metoprolol within 12 hours.
Researcher:
Mustafa Musa Khalaf Namoq
Drug Substance:
Metoprolol Tartrate
Formulations Prepared:
16 Formulas
Optimized Formula:
F14 — 86.24% Release in 12 Hours
Methodology:
Quality by Design (QbD)
The aim of the study was to develop and evaluate a novel expandable, swelling-based gastroretentive drug delivery system for Metoprolol Tartrate, contributing to improved bioavailability and sustained drug release over an extended therapeutic period.
Postgraduate Studies Committee
College of Pharmacy | University of Basrah
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