A Master's thesis was defended at the College of Pharmacy, University of Basrah, by the student Israa Saad, entitled "Preparation of Solid Dispersion Systems to Increase the Solubility of Poorly Water-Soluble Drugs Using Candesartan Cilexetil as a Model".
The study aimed to enhance the solubility of Candesartan, an AT1 receptor blocker used to treat hypertension and heart failure, with the goal of increasing its absorption and bioavailability. The research explored how treating the drug with Eudragit polymer led to the formation of a "Solid Dispersion," converting the drug from its poorly soluble crystalline form to a highly soluble amorphous state.
The thesis concluded that treating the drug with Eudragit polymer at a 1:5 ratio (drug:polymer) resulted in an exceptional increase in solubility—up to 27,000 times compared to the pure powder. Laboratory tests confirmed ideal miscibility without chemical interactions, validating the system's effectiveness in structural conversion for optimized therapeutic advantage.
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