A master's thesis in the College of Pharmacy at the University of Basrah researched (preparation of ethosomes loaded with the drug and evaluation ) L ( (ascorbic acid to enhance permeability . by the student Murtada Majeed Muhammad Ethosome acid and was evaluated ex vivo dealt with the study of preparation It contains ascorbic using the thin membrane method , where 24 compositions containing different percentages of phospholipids, different volumes, and different organic solvents were prepared to obtain the best . composition and particle size distribution included The thesis, the compositions prepared in the study were studied, their external appearance , pH , the volume of the resulting vesicles, as well as the study of different types of . variables on the average size of the vesicles and the index of polydispersion And It concluded The message is that using these quantities, the best average particle size (176 nm) was obtained, the value of the polydispersion index was ( 0.243 ), the efficiency of containing the treatment inside the skin was (89.8%), the physical stability after storage For . seven days at 8 ° C it was fine analysis of the best analytical formula was by scanning electron microscope and selective electron microscope, and the result was that the structure was spherical and smooth, and the crystalline structure was free from any treatment, and the results were a decrease in the intensity of the peak when compared with the pure treatment and the permeability outside the body in addition to that the treatment permeability test to the skin showed that the permeability of the therapeutic combination is twice as high as the formula that does not contain phosphate fats