a master's thesis in the Pharmaceutical Chemistry Department at the College of Pharmacy at the University of Basrah, entitled (Preparation, characterization and study of the biological activities of new pharmaceutical compounds from crown ethers) by a master's graduate student Marwan Majid Kazem.
 The thesis aims to manufacture and prepare new pharmaceutical compounds from Schiff bases and some esters as intermediate carriers to overcome some problems in the pharmacokinetic and pharmaceutical structure and improve the physical and chemical properties with a modification in the composition of some medicines to improve their biological activities
 The thesis included the preparation of some pharmaceutical compounds for Schiff bases by converting the crown dibenzene to the crown aldehyde containing two carbonyl groups and then the condensation reaction of similar nucleotides containing groups of nucleophilic primary amines (cyclovir, cytarabine and cladribine) with the aldehyde compound.  The prepared preparation for the preparation of highly effective pharmaceutical compounds to inhibit the growth and proliferation of cancer cells using the 1-THP cell line for leukemia (leukemia).
 The thesis also included the preparation of esterified pharmaceutical compounds by adding thionyl chloride to some quinolones that contain in their molecular structure the active carboxyl group (ciprofloxacin, levofloxacin and nalidixic acid) to prepare acyl chloride, which in turn reacts with the 2-hydroxymethyl ether-15-crown-5  Presence of pyridine to prepare esters
 The results show antitumor activity compared to the primary nucleotides used with a significant decrease in viable cells and this activity depends on the gradual increase in the concentration.
 The study also concluded a significant increase in the biological activity of levofloxacin against positive bacteria with a noticeable increase for the rest of the compounds for different types of negative and positive aerobic bacteria depending on the increase in the concentrations used by avoiding bacterial resistance due to the change in the molecular structure of the primary quinolones.

​​​​​​​