The College of Pharmacy at the University of Basrah thoroughly researched and examined a master's thesis focused on analyzing (The Pulmonary Therapeutic Effects of Hydrosmin and/or Vitamin C against Bleomycin-Induced Lung Toxicity).
The scientific study, presented by the researcher and student Mohammed Jabbar Makki, distinctly included evaluating the therapeutic potential and effect of oral Hydrosmin treatment (whether administered with or without the accompanying support of) Vitamin C, specifically counteracting the severe toxic doses caused by the drug Bleomycin.
The thesis primarily aimed to meticulously evaluate the cellular mechanisms driving Bleomycin-induced lung toxicity. It achieved this by comprehensively measuring a variety of specific biomarkers and factors related to inflammation and oxidative stress, such as (TNF, TGF, GSH, and TAS). Furthermore, the study sought to rigorously evaluate the therapeutic and protective effects provided by the compound Hydrosmin (either administered alone or evaluated in active combination with Vitamin C) to effectively mitigate severe lung tissue damage.
In conclusion, the study successfully established and conclusively proved the significant therapeutic effect of Hydrosmin in combating pulmonary toxicity and directly alleviating the severe cellular damage caused by Bleomycin induction.
